Skip to main content
. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Biomaterials. 2010 Jul 24;31(31):7978–7984. doi: 10.1016/j.biomaterials.2010.07.026

Fig. 1.

Fig. 1

Illustration of the composite retinal graft model. Top: The in vivo host retina is dependent on a dual blood supply. The choroid supplies the photoreceptors in the outer nuclear layer (ONL) while the retinal vessels supply the inner retinal cells in the inner nuclear and ganglion cell layer (INL and GCL). Middle: When the composite graft, consisting of photoreceptors in a transplant outer nuclear layer (tONL) fused with a PGS membrane, is placed in the subretinal space, the membrane blocks the nutritive support to the host ONL which induces ischemia and removes host photoreceptors. Bottom: Following PGS membrane degradation, the remaining inner retina of the host integrates with the transplanted photoreceptors (tONL) creating a new retina with all normal layers.