Table 2.
Associations of Quartiles of Soluble Endothelial Cell–Selective Adhesion Molecule With Baseline CKD Assessed by eGFR and ACR
| Q1 | Q2 | Q3 | Q4 | P Overall | |
|---|---|---|---|---|---|
| eGFR <60 mL/min per 1.73 m2 | |||||
| Unadjusted OR | Ref | 1.41 | 3.22 | 16.0 | <0.0001 |
| 99.83% CI | 0.59–3.36 | 1.46–7.11 | 7.43–34.41 | ||
| P value | 0.2212 | <0.0001 | <0.0001 | ||
| Adjusted* OR | Ref | 1.12 | 2.56 | 11.44 | <0.0001 |
| 99.83% CI | 0.43–2.89 | 1.07–6.12 | 4.89–26.76 | ||
| P value | 0.7454 | 0.0016 | <0.0001 | ||
| Adjusted* plus ACR | Ref | 1.12 | 2.53 | 9.58 | <0.0001 |
| 99.83% CI | 0.42–3.03 | 1.02–6.3 | 3.87–23.73 | ||
| P value | 0.7177 | 0.0014 | <0.0001 | ||
| ACR ≥30 mg/g | |||||
| Unadjusted OR | Ref | 0.75 | 1.12 | 3.52 | <0.0001 |
| 99.83% CI | 0.28–2.02 | 0.45–2.75 | 1.61–7.69 | ||
| P value | 0.3557 | 0.7044 | <0.0001 | ||
| Adjusted* OR | Ref | 0.95 | 1.36 | 5.23 | <0.0001 |
| 99.83% CI | 0.31–2.89 | 0.47–3.93 | 1.96–13.91 | ||
| P value | 0.8788 | 0.3598 | <0.0001 | ||
| Adjusted* plus eGFR | Ref | 0.82 | 1.05 | 2.83 | 0.0006 |
| 99.83% CI | 0.27–2.52 | 0.35–3.11 | 0.93–8.6 | ||
| P value | 0.5888 | 0.8965 | 0.00334 | ||
Threshold P value for significance=0.0017. P overall gives results of test of heterogeneity. ACR indicates albumin-to-creatinine ratio; CI, confidence interval; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; OR, odds ratio; Q, quartile; and Ref, reference.
*
Adjusted for age, race, sex, hypertension, pack-years, type 2 diabetes mellitus, high-density lipoprotein, low-density lipoprotein, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, statins, and high-sensitivity C-reactive protein.