Table 4.

Associations of Quartiles of Soluble Endothelial Cell–Selective Adhesion Molecule With Rapid Loss (>3% Per Year) in Kidney Function

	Unadjusted OR; 99.83% CI; P Value	Adjusted* OR; 99.83% CI; P Value	Adjusted* Plus ACR; 99.83% CI; P Value
Q1	Ref	Ref	Ref
Q2	1.18; 0.44–3.12; 0.6018	1.09; 0.38–3.13; 0.8056	1.12; 0.37–3.36; 0.7489
Q3	1.16; 0.43–3.13; 0.6359	0.94; 0.3–2.93; 0.8702	0.99; 0.31–3.19; 0.9869
Q4	2.52; 0.99–6.41; 0.0019	2.13; 0.65–7.01; 0.0465	2.01; 0.58–6.93; 0.0783
P overall	0.0043	0.0659	0.0157
Q4 vs Q1–Q3	2.28; 1.11–4.65; 0.0003	2.11; 0.86–5.22; 0.0095	1.94; 0.76–4.93; 0.0265

Threshold P value for significance=0.0017. P overall gives results of test of heterogeneity. ACR indicates albumin-to-creatinine ratio; CI, confidence interval; eGFR, estimated glomerular filtration rate; OR, odds ratio; Q, quartile; and Ref, reference.

^*Adjusted for age, race, sex, hypertension, pack-years, type 2 diabetes mellitus, high-density lipoprotein, low-density lipoprotein, angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, statins, high-sensitivity C-reactive protein, and baseline eGFR.