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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Angew Chem Int Ed Engl. 2013 Nov 19;52(52):13975–13979. doi: 10.1002/anie.201305882

Scheme 1.

Scheme 1

The preparation of 1; a divalent zinc chelator presenting both biotin and azide moieties. Complex 1 is comprised of 1 bonded to the pSer474 of the 32 amino acid peptide fragment of Akt2. The graphic of complex 1 (bottom right; constructed using PYMOL[18] and ChemBio3D Ultra) illustrates the scale of 1 (purple) bonded to pS474 on the polypeptide (blue).