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Retrosynthetic analysis of staurosporine analogues based on butatriene-enabled cycloadditions. With the goal of step-economically generating a library of simplified staurosporine analogues with selective kinase inhibitory function (FOS: function-oriented synthesis), we envisaged a 1,2,3-butatriene (V) reacting first in a [5+2] cycloaddition to provide a 1,3-diene ready for a subsequent [4+2] cycloaddition.
