Table 1.
Clinical characteristics of 5-year survivors of acute lymphoblastic leukemia
|
ALL survivors |
Chemotherapy only |
CRT |
TBI |
|||||
|---|---|---|---|---|---|---|---|---|
| n = 213 | % | n = 104 | % | n = 95 | % | n = 14 | % | |
| Age at diagnosis |
|
|
|
|
|
|
|
|
| <5 yrs |
111 |
52.1 |
61 |
58.7 |
45 |
47.4 |
5 |
35.7 |
| 5-9 yrs |
71 |
33.3 |
34 |
32.7 |
33 |
34.7 |
4 |
28.6 |
| 10-17 yrs |
31 |
14.6 |
9 |
8.7 |
17 |
17.9 |
5 |
35.7 |
| Period of diagnosis |
|
|
|
|
|
|
|
|
| 1970-1979 |
42 |
19.7 |
3 |
2.9 |
39 |
41.1 |
0 |
0 |
| 1980-1989 |
78 |
36.6 |
39 |
37.5 |
32 |
33.7 |
7 |
50.0 |
| 1990-1999 |
93 |
43.7 |
62 |
59.6 |
24 |
25.3 |
7 |
50.0 |
| Age at end of follow-up |
|
|
|
|
|
|
|
|
| 10-19 yrs |
54 |
25.4 |
46 |
44.2 |
6 |
6.3 |
2 |
14.3 |
| 20-29 yrs |
71 |
33.3 |
39 |
37.5 |
26 |
27.4 |
6 |
42.9 |
| 30-39 yrs |
73 |
34.3 |
15 |
14.4 |
53 |
55.8 |
5 |
35.7 |
| >40 yrs |
15 |
7.6 |
4 |
3.8 |
10 |
10.5 |
1 |
7.1 |
| Relapse |
24 |
11.3 |
2 |
1.9 |
11 |
11.6 |
11 |
78.6 |
| Stem cell transplantation |
14 |
6.6 |
0 |
0 |
0 |
0 |
14 |
100.0 |
| Cranial irradiation |
|
|
|
|
|
|
|
|
| 12-15 Gy |
2 |
0.9 |
|
|
2 |
2.1 |
0 |
0 |
| 18 Gy |
28 |
13.1 |
|
|
28 |
28.4 |
1 |
7.1 |
| 20-23 Gy |
6 |
2.8 |
|
|
6 |
6.3 |
0 |
0 |
| 24-30 Gy |
62 |
29.1 |
|
|
60 |
63.2 |
2 |
14.3 |
| Total body irradiation |
|
|
|
|
|
|
|
|
| 8-12 Gy | 14 | 6.6 | 14 | 100.0 | ||||
Abbreviations:ALL acute lymphoblastic leukemia, CRT received cranial irradiation in addition to chemotherapy, TBI received total body irradiation in addition to chemotherapy, including three cases who, in addition, received cranial irradiation.