Table 3.

Feasibility outcomes and estimated sample sizes

Outcome	Demonstration of feasibility	Estimated actual proportion	Desired precision	Required sample size
Administration of first dose of albumin within two hours of furosemide administration	Lower-bound of 95% confidence interval greater than 85%	0.925	0.075	47
Administration of at full 72 hours of study treatment	Lower-bound of 95% confidence interval greater than 80%	0.9	0.1	34
Absence of hyperoncotic albumin in control arm	Lower-bound of 95% confidence interval greater than 85%	0.95	0.1	18
Randomization rate of patients eligible by screening criteria	Lower-bound of 95% confidence interval greater than 50%	0.65	0.15	39