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. 2014 Apr 15;289(24):16855–16865. doi: 10.1074/jbc.M114.564005

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 2. — Comparison of the conformational states of nNOS and nNOS-CaM by EM. A and B, representative averages and single particle images from each class, highlighting an extended-to-closed conformational change for the nNOS dimer (A) and nNOS-CaM (B, left panel), with the indicated location of the reductase domain (Red), oxygenase dimer (Oxy), and CaM. B, right panel, representative averages and single particles of nNOS-CaM are shown highlighting conformational changes in the reductase domain. The number of single particle images for each average is shown (scale bar = 100 Å). C, bar graph showing the fraction of nNOS and nNOS-CaM single particles that adopt extended, intermediate V-shaped, or closed conformations, based on the arrangements identified in the two-dimensional averages.