FIGURE 6.
Predicted transmembrane topology map of the active site of Porcn. Graphical representation of the predicted topology of Porcn as generated by Protter Server (37). MBOAT homology domain (circles) and FDH-associated mutants (squares) are highlighted according to their effect on Porcn PAT activity. Red boxes represent residues that are essential for enzymatic activity (inactive mutants), and green boxes indicate residues that are not required for PAT activity (active mutants).