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UVA photolysis of hIDO/hSVCT2 transgenic mouse lenses results in AGE formation. The lenses from 1-month-old hIDO/hSVCT2 transgenic or wild type (WT) mice (3 pairs each) in AAH were either UVA-irradiated or kept in the dark (dark control; D/C). Then the lenses were incubated for 7 days at 37 °C. The AGEs (A, pentosidine; B, argpyrimidine; and C, CML) were determined by HPLC. Bars, mean ± S.D. from three independent measurements.
