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Tyrosine phosphorylation of Tyr510 regulates Dbl intracellular localization and activity. Cells expressing wild-type Dbl, Dbl(Y510F), or control vector, were immunostained with anti-Dbl-antibody (green) and Texas Red-conjugated phalloidin (red) and visualized by fluorescence microscopy. Arrowheads indicate stress fibers (SF), lamellipodia (L), or filopodia (F). Scale bar, 10 μm.
