Skip to main content
. 2014 Apr 24;289(24):17228–17239. doi: 10.1074/jbc.M113.522565

FIGURE 5.

FIGURE 5.

The monoclonal Abs bind in a species-dependent manner to FcRn. A, SDS-PAGE gel migration of recombinant GST-tagged human, macaque, pig, dog, mouse, and rat FcRn showing the expected molecular sizes of the GST-fused HCs and β2-microglobulin (β2m). ELISA binding of human, macaque, pig, dog, mouse, and rat FcRn toward DVN1 (B), ADM31 (C), ADM32 (D), DVN24 (E), ADM11 (F), ADM12 (G), DVN21 (H), DVN22 (I), and DVN23 (J) at pH 7.4 (n = 3). All data are presented as mean ± S.D. An overview of relative binding of the Abs to the FcRn species is given in Table 2.

HHS Vulnerability Disclosure