TABLE 2.

Cross-species binding properties of anti-FcRn monoclonal antibodies

Relative binding was determined based on ELISA screening (Fig. 5, B–J), and data are presented as equal binding as hFcRn (+++), partly reduced binding (++), poor binding (+), or no binding (−).

FcRn/Ab	DVN1	DVN21	DVN22	DVN23	DVN24	ADM11	ADM12	ADM31	ADM32
Human	+++	+++	+++	+++	+++	+++	+++	+++	+++
Macaque	+++	+++	+	++	+++	+++	+++	+++	+++
Pig	−	−	++	+	+++	+++	+++	+++	+++
Dog	−	−	−	+	+++	+++	+++	++	++
Rat	−	−	−	−	−	−	−	−	−
Mouse	−	−	−	−	−	−	−	−	−