Table 1.
Effects of BPSDL and nitrate pretreatment on gastric nitrate, nitrite, and NO levels; mucosal blood flow; and UI in rats subjected to WIRS.
| Gastric nitrate (µmol/L; n = 6) | Gastric nitrite (µmol/L; n = 6) | Luminal NO (ppb; n = 6) | Blood flow (PU; n = 6) | Ulcer index (mm; n = 6) | |
|---|---|---|---|---|---|
| Sham | 54.2 ± 19.9 | 2.05 ± 0.61 | 93 ± 22 | 47.24 ± 18.33 | 14.2 ± 11.7 |
| Sham + nitrate | 345.2 ± 210.7 | 6.37 ± 2.37 | 720 ± 230 | 69.34 ± 11.81 | 10.2 ± 6.9 |
| BPSDL | 21.3 ± 12.6a | 0.70 ± 0.26a | 36 ± 15a | 35.03 ± 10.79a | 34.3 ± 13.6a |
| BPSDL + nitrate | 249.3 ± 130.7b | 3.48 ± 1.65b | 404 ± 102b | 55.61 ± 18.41b | 14.7 ± 6.7b |
Nitrate treatment groups were given 1 mmol/kg bw of NaNO3 in drinking water for 1 week before the WIRS experiment. The sham and BPSDL groups were given NaCl of the same dose. Each value represents the mean ± SD.
p < 0.05 compared to sham.
p < 0.05 compared to BPSDL.