Skip to main content
. Author manuscript; available in PMC: 2015 May 15.
Published in final edited form as: Clin Cancer Res. 2014 Mar 21;20(10):2684–2694. doi: 10.1158/1078-0432.CCR-13-3268

Figure 5. GBM tumor RNA-pulsed dendritic cells stimulate CMV pp65-specific T cells.

Figure 5

T cells were stimulated with autologous DCs pulsed with GBM tumor RNA (total RNA isolated from autologous primary GBM tumor cells) and tested for CTL activity. DCs pulsed with either CMV pp65 RNA or Flu M1 RNA were used as target cells.

A) GBM tumor-specific T cells specifically lyse CMV pp65-expressing DC targets but not Flu M1-expressing DC targets. Data using cells from Patient 4 and Patient 5 are depicted.

B) T cells stimulated with GBM tumor RNA-pulsed DCs expand CMV pp65-specific CD8+ T cells. T cells from the same patient PBMCs stimulated with Flu M1 RNA-pulsed DCs were used as controls and do not demonstrate the presence of CMV pp65-specific CD8+ T cells.

Figure represents data using cells from Patient 4.