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. 2014 May 9;57(11):4849–4860. doi: 10.1021/jm500389b

Table 3. Metal Competition^a.

	% intact starting species by incubation time
	1 h		1 d		5 d		7 d
competing metal cation	⁸⁹Zr-HOPO	⁸⁹Zr-DFO	⁸⁹Zr-HOPO	⁸⁹Zr-DFO	⁸⁹Zr-HOPO	⁸⁹Zr-DFO	⁸⁹Zr-HOPO	⁸⁹Zr-DFO
Co²⁺	98.5 ± 2.2	92.5 ± 0.4	98.2 ± 2.6	93.4 ± 3.1	98.6 ± 2.0	96.2 ± 0.5	98.9 ± 1.6	95.8 ± 1.1
Cu²⁺	98.2 ± 2.5	95.8 ± 4.0	98.1 ± 2.7	98.2 ± 2.6	98.3 ± 2.4	96.8 ± 1.5	98.4 ± 2.3	95.3 ± 0.2
Fe³⁺	97.0 ± 4.2	90.6 ± 4.5	89.8 ± 5.4	48.2 ± 27.0	90.5 ± 3.8	51.9 ± 11.2	83.0 ± 4.2	39.1 ± 9.9
Ga³⁺	98.4 ± 2.3	94.2 ± 5.6	97.9 ± 3.0	94.9 ± 4.3	97.3 ± 1.9	93.0 ± 4.4	96.4 ± 0.6	91.1 ± 2.2
Gd³⁺	98.2 ± 2.6	94.3 ± 1.4	97.8 ± 3.1	95.0 ± 2.7	96.5 ± 2.9	98.4 ± 2.2	94.5 ± 4.1	97.0 ± 0.7
K⁺	99.0 ± 1.5	97.2 ± 4.0	98.7 ± 1.9	94.8 ± 3.5	98.5 ± 2.2	97.6 ± 0.7	98.1 ± 0.7	97.0 ± 1.6
Mg²⁺	98.3 ± 2.5	94.4 ± 0.02	98.3 ± 2.5	95.6 ± 2.5	98.6 ± 2.0	98.1 ± 0.8	98.7 ± 1.8	96.5 ± 0.1
Ni²⁺	98.4 ± 2.3	97.2 ± 4.0	98.4 ± 2.2	94.9 ± 3.2	98.7 ± 1.9	97.0 ± 1.2	97.4 ± 0.1	97.8 ± 1.1
Zn²⁺	98.6 ± 2.0	92.9 ± 2.2	98.7 ± 1.9	97.9 ± 3.0	97.7 ± 3.3	97.6 ± 3.4	98.3 ± 2.4	96.4 ± 1.3

^a

Radiolabeled ligand complexes were incubated with a 10-fold excess of various biologically relevant metal salts in PBS at a pH of 7.4 at 37 °C for 7 days. The experiment was repeated twice.