Table 1. Optimization of Reaction Conditions^a.

entry	Pd(OAc)2 (mol %)	base	solvent	temp (°C), time	yieldb (%)
1	10	KOAc	DMF	100, 30 min	19
2	10	KOAc	DMF	120, 30 min	36
3	10	KOAc	DMF	140, 30 min	42
4	10	KOAc	DMF	160, 30 min	66
5	10	KOAc	DMF	170, 30 min	51
6	10	KOAc	DMF	180, 30 min	49
7	10	KOAc	DMF	160, 1 h	84
8	2	KOAc	DMF	160, 1 h	45
9	4	KOAc	DMF	160, 1 h	56
10	6	KOAc	DMF	160, 1 h	68
11	8	KOAc	DMF	160, 1 h	78
12	10	CsOAc	DMF	160, 1 h	67
13	10	NaOAc	DMF	160, 1 h	54
14	10	K2CO3	DMF	160, 1 h	35
15	10	Cs2CO3	DMF	160, 1 h	23
16	10	KOAc	DMAc	160, 1 h	77
17	10	KOAc	NMP	160, 1 h	62
18	10	KOAc	xylene	160, 1 h	35
19	10	KOAc	dioxane	160, 1 h	24
20	10	KOAc	butan-1-ol	160, 1 h	11

^aReaction conditions: 1a (1 mmol), 2a (1 mmol), 3a (2 mmol), base (2 mmol), solvent (6 mL).

^bIsolated yield.