Table 1. List of Cancer-Associated Genes on Chromosome 22.
| cancer gene list
for chromosome 22 | ||||||
|---|---|---|---|---|---|---|
| position | oncogene | Sanger(S)/Waldman(W)/cancer index(C)a | top Novoseek cancer associationb | GeneCards Novoseek-logPc | adjacent cancer-related genes scored | gene densitye |
| 22q11.21 | BID | C | tumors | 52.3 | 4 | 90 |
| CLTCL1 | S | n/a | n/a | 12 | 100 | |
| COMT | C | breast cancer | 49.4 | 17 | 100 | |
| CRKL | W,C | chronic myeloid leukemia | 77.7 | 0 | 98 | |
| SEPT5 | S | leukemia | 0 | 21 | 100 | |
| 22qll.23 | BCRf | S,W,C | chronic myeloid leukemia | 91.4 | 6 | 130 |
| GSTT1 | C | bladder cancer | 56.9 | 16 | 251 | |
| MIF | C | tumors | 44.9 | 16 | 251 | |
| MMP11 | C | breast carcinoma | 64.3 | 21 | 251 | |
| SMARCB1 | S,C | rhabdoid tumor | 97 | 16 | 251 | |
| 22ql2.1 | CHEK2 | S,C | breast cancer | 54.6 | 13 | 52 |
| MN1 | S,C | meningioma | 68.3 | 12 | 21 | |
| 22ql2.2 | EWSR1 | S,C | Ewing’s sarcoma | 96.3 | 13 | 52 |
| LIF | C | leukemia | 94.9 | 8 | 70 | |
| NF2f | S,W,C | schwannoma tumors | 89.9 | 13 | 52 | |
| PATZ1 | S | colon carcinoma | 35.6 | 0 | ||
| 22ql2.3 | MYH9 | S | leukemia | 17.9 | 6 | 44 |
| TIMP3 | W | tumors | 57.7 | 1 | 23 | |
| 22ql3.1 | MKL1 | S | acute megakaryoblastic leukemia | 78.3 | 5 | 36 |
| PDGFBf | S,W,C | glioma* | 50.4 | 10 | 84 | |
| 22ql3.2 | BIK | C | breast cancer | 14.3 | 3 | 40 |
| CYP2D6 | W,C | breast cancer | 26.4 | 6 | 110 | |
| EP300 | S | leukemia | 60.5 | 5 | 68 | |
| 22ql3.33 | TYMP | W | tumors | 71.4 | 3 | 72 |
Websites that list oncogene information are http://www.sanger.ac.uk/genetics/CGP/Census/, http://waldman.ucsf.edu/GENES/completechroms.html, and http://www.cancerindex.org/geneweb/genes_d.htm.
Top cancer association from GeneCards Novoseek disease relationship table, http://www.genecards.org/.
-logP of top cancer association (b) from GeneCards Novoseek disease relationship table, http://www.genecards.org/.
Information derived from neXtProt and GeneCards. As a way to assess degree of cancer association, we have calculated a score as follows: the adjacent 10 genes on either side of the oncogene (from neXtProt) are scored as oncogene designation +5 points, direct literature association with cancer +3 points, present in cancer data sets +1 point.
The gene density was derived from GeneCards: http://genecards.weizmann.ac.il/geneloc-bin/gene_densities.pl. All values represent the regions with a gene density above the average on chromosome 22 (i.e., 51.6 genes/Mb), except for numbers indicated in bold.
Recognized as driver oncogene.
Italic text indicates known gene mutation associated with cancer.
Bold text and * indicates cancer gene target with therapy from My Cancer Genome, http://www.mycancergenome.org/.