Table 1. Factor Analysis for Intracellular Metabolites.
| correlation coefficienta,b |
||
|---|---|---|
| metabolite | PC1 | PC2 |
| acetate | 0.962 | –0.027 |
| creatine | 0.961 | –0.038 |
| caprylate | 0.955 | –0.024 |
| acetone | 0.933 | –0.042 |
| formate | 0.928 | –0.082 |
| 2-hydroxybutyrate | 0.876 | 0.024 |
| choline | 0.866 | 0.084 |
| betaine | 0.858 | 0.156 |
| acetoin | -0.828 | 0.124 |
| lactate | 0.811 | 0.023 |
| methanol | 0.797 | –0.139 |
| glutamate | 0.790 | 0.023 |
| alanine | 0.743 | 0.232 |
| ornithine | 0.725 | 0.355 |
| succinate | -0.713 | 0.237 |
| aspartate | –0.584 | –0.171 |
| arginine | –0.458 | 0.713 |
| acetoacetate | –0.450 | –0.247 |
| leucine | –0.442 | 0.746 |
| glutamine | –0.433 | 0.752 |
| creatinine | –0.389 | 0.595 |
| isovalerate | –0.367 | -0.537 |
| 2-hydroxyvalerate | –0.364 | -0.695 |
| glutarate | –0.361 | 0.569 |
| 3-hydroxybutyrate | –0.344 | –0.662 |
| 4-aminobutyrate | –0.322 | –0.581 |
| isobutyrate | –0.322 | –0.611 |
| serine | –0.290 | –0.512 |
| cystathionine | –0.289 | 0.631 |
| asparagine | –0.289 | 0.629 |
| trans-aconitate | –0.285 | 0.604 |
| threonate | –0.261 | –0.439 |
| propionate | –0.243 | –0.481 |
| 2-hydroxyglutarate | –0.222 | –0.466 |
| creatine phosphate | –0.222 | –0.466 |
| isocitrate | –0.222 | –0.466 |
| sarcosine | –0.222 | –0.466 |
| succinylacetone | –0.222 | –0.466 |
| 3-hydroxyphenylacetate | –0.203 | 0.503 |
| acetamide | –0.203 | 0.503 |
| percent total variance | 30.37% | 17.44% |
| cumulative percent variance | 47.81% | |
a
Significance of correlation coefficient set at threshold of 0.4.
b
Correlation coefficient numbers in bold indicate metabolites for which the statistical relatedness of the variable is most correlated to the PC, as indicated by the square of the cosine.