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Assessment of estrogenic properties of different stable isomers of tamoxifen’s metabolites 4OHT and endoxifen in MCF-7:WS8 at average therapeutic concentrations.26 The levels for the tested compounds corresponding to mean therapeutic levels of tamoxifen metabolites were the following: ZFR4OHT, 5.81 × 10–9 M; ZFREndox, 29.1 × 10–9 M; EFR4OHT, 5.6 × 10–9 M; EFREndox, 1.17 × 10–9 M.
