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. 2014 May 13;13(6):2910–2919. doi: 10.1021/pr5000686

Figure 6.

Figure 6

Activation of the phosphocholine pathway with aging. (A) Relative concentrations in arbitrary units of phosphocholine in young and 7-day-old adult WT, slcf-1(tm2258), daf-18(e1375), and daf-18(e1375);slcf-1(tm2258) double mutants. Results are reported with means and 95% confidence intervals. (B) Relative concentrations in arbitrary units of ckb-2 mRNA in young and 7-day-old adults WT, slcf-1(tm2258), daf-18(e1375) and daf-18(e1375);slcf-1(tm2258) double mutants. Results are reported with means and standard deviations. See SI Table S2 for detailed data and statistical tests for comparison. (C) Survival curves of OLB11 worms fed control (HT) or ckb-2RNAi bacterial clones. OLB11 strain allows RNAi inactivation of genes in the intestine only. Data from three independent experiments have been pooled. The corresponding lifespans were 23.3 ± 0.2 (n = 208) and 19.9 ± 0.4 (n = 228), respectively, for wild-type and ckb-2RNAi-treated worms. Comparison with log rank test: p < 10–3.