Table 5.
Inhibitory effect of Agaricus brasiliensis polysaccharides in A549 cell proliferation (MTT assay)
| Sample | 48 h
|
72 h
|
Increase in Cytotoxicity
|
||
|---|---|---|---|---|---|
| EC50a | 95 %Confidence Interval | EC50a | 95 %Confidence Interval | EC50 48 h/ EC50 72 h | |
| FR | >1500 | - | 1147 | 1006 to 1307 | >1.3 |
| FR-S | 605.6 | 440.6 to 832.5 | 222.5 | 153 to 323.6 | 2.7 |
| MI | >1500 | - | >1500 | - | - |
| MI-S | 342.1 | 275.4 to 425.1 | 60.66 | 50.41 to 73 | 5.6 |
| DEX | >1500 | - | >1500 | - | - |
| DEX-S | 991.6 | 600.5 to 1638 | 783.1 | 560.6 to 1094 | 1.3 |
| Paclitaxel | 0.31 | 0.22 to 0.45 | 0.056 | 0.03 to 0.11 | 5.5 |
FR and FR-S, A. brasiliensis fruiting body polysaccharide and its sulfated derivative;
MI and MI-S, A. brasiliensis mycelial polysaccharide and its sulfated derivative;
DEX and DEX-S, dextran (410 kDa) and dextran sulfate (> 500 kDa), Sigma.
a
50 % effective concentration (μg/mL)