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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: J Immunol. 2010 Dec 20;186(3):1598–1607. doi: 10.4049/jimmunol.1003304

FIGURE 5.

FIGURE 5

CD8 T cells play a minor role in the increased susceptibility of PD-1 KO mice to M. tuberculosis infection. A and B, Weight loss (A) and survival (B) of WT and PD-1 KO mice treated with CD8 T cell-depleting Abs on days 20 and 25 postinfection with M. tuberculosis. Data are representative of two independent experiments. C and D, TCRα KO mice were reconstituted with WT CD4 T cells and either WT CD8 T cells or PD-1 KO CD8 T cells and then infected with M. tuberculosis (C) and survival was monitored (D). p < 0.05. Data are representative of two independent experiments. E, Survival of M. tuberculosis-infected WT (n = 10), CD8 KO (n = 10), PD-L1 KO (n = 22), and PD-L1/CD8 double-KO (n = 18) mice.

HHS Vulnerability Disclosure