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Histograms showing the risk allele burden of patients with schizophrenia (cases) and controls in the follow-up study. Risk allele burden is defined as the count of risk alleles across 358 successfully genotyped single nucleotide polymorphisms (SNPs) in each individual. Cases harbor significantly more risk alleles in the set of 358 SNPs (mean = 331.7) than controls (mean = 329.3) with a P value of 7.78×10−8 in the logistic regression test.
