Table 1.
Summary of Findings Table
| Active Education + Support for Implementation vs Routine Care or Passive Dissemination for Participants With Schizophrenia and Related Psychosis | |||||
|---|---|---|---|---|---|
| Outcomes | Illustrative Comparative Risks (95% CI) | Relative Effect (95% CI) | Number of Participants (Studies) | Quality of the Evidence (GRADE) | |
| Assumed Risk | Corresponding Risk | ||||
| Routine Care or Passive Dissemination | Active Education + Support for Implementation | ||||
| Polypharmacy | 441 per 1000 | 428 per 1000 (331–552) | RR 0.97 (0.75–1.25) | 310 (2 studies) | Very lowa, b |
| Not screened for cardiovascular risk factors | 895 per 1000 | 635 per 1000 (429–922) | RR 0.71 (0.48–1.03) | 38 (1 study) | Very lowa, c |
| Global state (PANSS total score) | Mean global state—PANSS total score—design effect corrected in the intervention groups was 01.30 lower (10.52 lower to 7.92 higher) | 59 (1 study) | Very lowd, e | ||
| Satisfaction with care (ZUF8) | Mean satisfaction with care—ZUF8—design effect corrected in the intervention groups was 0.10 higher (1.96 lower to 2.16 higher) | 46 (1 study) | Very lowd, e | ||
| Lack of treatment adherence | 385 per 1000 | 346 per 1000 (169–712) | RR 0.90 (0.44–1.85) | 52 (1 study) | Very lowe, f |
| Drug attitude (DAI) | Mean drug attitude—DAI—design effect corrected in the intervention groups was 1.40 lower (3.38 lower to 0.58 higher) | 32 (1 study) | Very lowd, e | ||
| Quality of life | No trial reported this outcome | ||||
Note: CI, confidence interval; DAI = Drug Attitide Inventory; PANSS, Positive and Negative Syndrome Scale; RR, risk ratio; ZUF8 = patient satisfaction questionnaire.
aRisk of bias: Rated—“very serious”—Randomization and allocation poorly described.
bImprecision: Rated—“serious”—Only 2 studies with a pooled treatment estimate ranging from substantial beneficial effect to substantial harmful effect.
cImprecision: Rated—“serious”—Only 1 study with few cases and events.
dRisk of bias: Rated—“serious”—Groups were not well balanced in terms of length of hospitalization and psychopathology ratings.
eImprecision: Rated—“very serious”—Only 1 study with few cases.
fRisk of bias: Rated—“serious”—Groups were not well balanced in terms of ethnic groups and psychopathology ratings.