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. 2014 Jun 3;14:302. doi: 10.1186/1471-2334-14-302

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Copyright © 2014 Santamaria et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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MALDI identification of human apolipoprotein A-I. MALDI MS-MS data confirms the identification of the 24.7 kDa biomarker to be a fragment of human APOA1. (A) MS Reflector Positive spectrum obtained from the in-gel trypsin digestion of the ~25 kDa band cut out from fraction 3 shows the precursor peaks generated by trypsin. (B) ProteinPilot MS-MS data shows that 8 peptides were sequenced and matched to human APOA1 with more than 95% confidence. (C) MS-MS sequence coverage. Peptides sequenced with more than 95% confidence (green) or less 95% confidence (red) together covered 47.7% of the full-length APOA1 human protein sequence.