Table 2.
Antinociceptive effect of METS 50, 100 and 150 mg/kg in acetic acid induced abdominal writhing test
| Samples | Dose | Number of writhes | % inhibition |
|---|---|---|---|
| 1% tween 80 |
10 ml/kg |
60.166 ± 4.167 |
- |
| METS |
50 mg/kg |
30.166 ± 4.070 |
49.862*** |
| 100 mg/kg |
22.833 ± 2.786 |
62.05*** |
|
| 150 mg/kg |
10.166 ± 2.786 |
83.103*** |
|
| Acetylsalicylic acid | 100 mg/kg | 15.166 ± 3.656 | 74.793 |
Results of multiple comparison Dunnetts test in one-way ANOVA; Groups significantly different *** p ≤ 0.001 when compared to positive control group. Percent inhibition was calculated in comparison to control group. F = 187.523, d.f. = 29. ED50 for analgesic effect of METS was 50.68 mg/kg (b.w). ***p ≤ 0.001, **p ≤ 0.01 and *p ≤ 0.05 vs. control group (n = 6).