Table 4.
Samples |
Dose mg/kg |
Tail withdrawing time in sec |
||||
---|---|---|---|---|---|---|
0 min | 30 min | 60 min | 90 min | 120 min | ||
1% tween 80 |
10 ml/kg |
3.45 ± 0.26 |
3.48 ± 0.19ns |
3.27 ± 0.032ns |
3.48 ± 0.20ns |
3.57 ± 0.19 |
METS |
50 mg/kg |
3.48 ± 0.19 |
3.57 ± 0.19ns |
4.11 ± 0.12ns |
4.16 ± 0.12ns |
4.09 ± 0.11ns |
100 mg/kg |
3.53 ± 0.18 |
4.25 ± 0.04ns |
4.49 ± 0.13ns |
4.39 ± 0.08ns |
4.29 ± 0.04ns |
|
150 mg/kg |
3.57 ± 0.19 |
4.82 ± 0.04ns |
5.48 ± 0.02ns |
5.27 ± 0.05ns |
5.18 ± 0.06ns |
|
TramadolR |
30 mg/kg |
3.48 ± 0.20 |
4.99 ± 0.33 |
5.69 ± 0.02 |
5.49 ± 0.06ns |
5.38 ± 0.05ns |
Antinociceptive effect of METS and TramadolR antagonized by Naloxone | ||||||
METS |
150 mg/kg |
3.52 ± 0.02 ns |
2.64 ± 0.01ns |
2.87 ± 0.02ns |
2.73 ± 0.01ns |
2.69 ± 0.01ns |
TramadolR | 30 mg/kg | 3.50 ± 0.02 | 2.35 ± 0.02 | 2.69 ± 0.01 | 2.75 ± 0.02 | 2.65 ± 0.02 |
nsValues statistically non significant when compared to control using one way ANOVA followed by Dunnett’s multiple comparison test.