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Prothrombin time at the low dabigatran (A), high dabigatran (B) and post-trauma (C) time points. Prothrombin time was obtained on a coagulometer using Innovin to determine the effect of ex vivo haemostatic therapy at various time points. Grey dotted lines indicate mean baseline values. *P <0.05 versus control. PCC, prothrombin complex concentrate; aPCC, activated PCC; rFVIIa, recombinant activated factor VII; aDabi-Fab, antibody fragment to dabigatran.
