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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Arch Biochem Biophys. 2013 Apr 4;535(2):143–149. doi: 10.1016/j.abb.2013.03.012

Fig. 4.

Fig. 4

Effect of siRNA down regulation of UGT1A9 and UGT2B7 mRNA expression on selective UGT probe substrate activities in human hepatocytes. Control Vmax values represent the maximal velocity achieved for each probe substrate in the absence of siRNA treatment. An asterisk (*) indicates a statistically significant difference, where p < 0.0001. Error bars indicate the standard deviation for replicate incubations (n = 3). The selective probe substrates used were estradiol (UGT1A1), fulvestrant (UGT1A3), trifluoperazine (UGT1A4), serotonin (UGT1A6), propofol (UGT1A9), hyodeoxycholic acid (UGT2B4) and morphine (UGT2B7).