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Comparison of the thermodynamic stability of mutant and WT proteins. Fit of the fraction of unfolded protein, Fapp, as a function of denaturant concentration for the equilibrium unfolding of IL-1Ra and C116F (cyan and yellow, respectively). The stability for C116F is greater than that observed for WT IL-1Ra as indicated by the shift of the observed transition curve to higher denaturant (right) concentrations.
