Table 2. Effects of EDCs on Leydig cell function in adult rodents^*.

EDCs	Exposure period	Dosage	Effects on Leydig cells	Refs.
PFOS	Adult mouse exposure for 21 days	5 or 10 mg/kg/day	↓ Pituitary LH mRNA level	[27]
			↓ Testicular IGF-1, IGF-1r and LHr gene expression
			↓ Steroidogenic enzyme expression
			↓ Serum testosterone
Cadmium	Single injection and sacrifice after 0.48 – 144 h in adult rats	10 μm/kg	↓ Testicular LHr mRNA level	[29]
Methylmercury	Adult rat exposure for 14 days	3 mg/kg/day	↓ Serum testosterone level	[141]

^*This Table is not intended to be exhaustive, only selected examples were used to highlight the effects of EDCs on Leydig cell function in adult rodents. Other references can be found in recent reviews [32,142,143].