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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Dev Biol. 2011 Sep 16;360(1):66–76. doi: 10.1016/j.ydbio.2011.09.001

Figure 5. Traf3ip1 mutant embryos have abnormalities in neural tube patterning consistent with defects in cilia mediated Hh signaling.

Figure 5

(Left Column) Traf3ip1WT neural tube sections and (Right Column) Traf3ip1GT mutant sections. (A and B) Sonic Hh labeling of the floor plate is absent in the Traf3ip1GT mutant embryo when compared to its Traf3ip1 WT littermate. (D and F) Sonic Hh responsive compartments are either absent or greatly diminished in Traf3ip1GT mutant embryos stained for Nkx6.1 or MNR2 when compared to (C and E) Traf3ip1 WT littermates. (G and H) The roof plate marker MSX is expanded in Traf3ip1GT mutants compared to Traf3ip1WT.