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Sequential progressive model of hepatic dysfunction on cytochrome P450 (CYP)-mediated clearance as described by Frye and colleagues [Frye et al. 2006]. According to the model, there is a defined order by which clearance by various CYP enzymes are affected by worsening hepatic function, explaining why some drugs are more sensitive to varying degrees of cirrhosis. Adapted from Frye et al. [2006].
