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Synthesis of 2-arylidenetetrahydrofurans through nucleophilic phosphine catalysis
 | |||||
|---|---|---|---|---|---|
| entry | R | 80 (equiv) | t(h) | yield (%) | E/Z ratio |
| 1 | 2-ClC6H4 | 2.4 | 18 | 94 | 4:1 |
| 2 | 2-FC6H4 | 1.8 | 24 | 81 | 4:1 |
| 3 | 2,4-Cl2C6H4 | 1.8 | 22 | 98 | 6:1 |
| 4 | 4-NO2C6H4 | 1.8 | 5 | 84 | 5:1 |
| 5 | 4-CF3C6H4 | 2.0 | 17 | 81 | 4:1 |
| 6 | 3-pyridyl | 1.8 | 5 | 81 | 20:1 |
| 7 | 2-furyl | 2.0 | 24 | 72 | 2:1 |
