Table 1. Full list of parameters for the glucose/insulin model [4] used in this paper; note that these are the model parameters we us in this paper.

Glucose model parameters and their TDMI relationships
Parameter	nominal value	meaning	linear correlation, p-value	linear regression (slope)	effect on TDMI
Vp	3 l	plasma volume	0.44, 0.05	4.6×10−5±6×10−4	—
Vi	11 l	insulin volume	0.28, 0.21	2.4×10−4±10−5	—
Vg	10 l	glucose space	0.9, 10−8	4×10−4±10−4
E	0.2 l min−1	exchange rate for insulin between remote and plasma compartments	0.15, 0.5	1.3×10−5±6×10−6	—
tp	6 min	time constant for plasma insulin degradation (via kidney and liver filtering)	−0.67, 10−3	−1×10−4±8×10−4
ti	100 min	time constant for remote insulin degradation	0.13, 0.57	1×10−5±6×10−4	—
td	12 min	delay between plasma insulin and glucose production	−0.82, 10−4	−5×10−4±2×10−3
Rm	209 mU min−1	linear constant affecting insulin secretion	0.72, 10−4	−1×10−4±7×10−4
a 1	6.67	exponential constant affecting insulin secretion	0.88, 10−7	7.4×10−4±3×10−3
C 1	300 mg l−1	exponential constant affecting insulin secretion	0.87, 10−7	9×10−4±3×10−10
C 2	144 mg l−1	exponential constant affecting IIGU	−0.04, 0.86	4×10−6±6×10−4	—
C 3	100 mg l−1	linear constant affecting IDGU	0.8, 10−6	−5×10−4±2×10−3
C 4	80 mU l−1	factor affecting IDGU	0.16, 0.47	2×10−4±7×10−4	—
C 5	26 mU l−1	exponential constant affecting IDGU	0.76, 10−5	1×10−4±7×10−4	—
Ub	72 mg min−1	linear constant affecting IIGU	0.87, 10−7	6×10−4±2×10−3
U 0	4 mg min−1	linear constant affecting IDGU	0.85, 10−7	3×10−4±1×10−3
Um	94 mg min−1	linear constant affecting IDGU	0.028, 0.9	2×10−6±6×10−4	—
Rg	180 mg min−1	linear constant affecting IDGU	−0.86, 10−7	−2×10−3±9×10−3
α	7.5	exponential constant affecting IDGU	−0.84, 10−6	−6×10−4±3×10−3
β	1.77	exponent affecting IDGU	−0.25, 0.26	−2.4×10−4±6×10−4	—