Table 1. Univariate analysis of prognostic factors for OS and EFS in medulloblastoma patients (n = 173).
Factors | No. of cases | 5-year OS(%) | p-value | 5-year EFS(%) | p-value |
Sex | |||||
Male | 112 | 49.8 | 0.216 | 43.2 | 0.384 |
Female | 61 | 55.5 | 48.6 | ||
Age | |||||
Children | 118 | 47.6 | 0.090 | 41.9 | 0.047 |
Adult | 55 | 62.7 | 51.7 | ||
Location | |||||
Midline | 152 | 50.2 | 0.219 | 43.7 | 0.228 |
Lateral | 21 | 65.3 | 54.9 | ||
Involvementa | |||||
Yes | 63 | 43.3 | 0.002 | 35.2 | 0.001 |
No | 84 | 63.8 | 55.2 | ||
Unknown | 26 | ||||
Tumor Size | |||||
<3 cm | 110 | 56.8 | 0.314 | 47.7 | 0.444 |
≥3 cm | 37 | 44.2 | 41.8 | ||
Unknown | 26 | ||||
Extent of resection | |||||
Gross total | 114 | 60.9 | 0.002 | 53.9 | <0.001 |
Subtotal | 52 | 42.7 | 33.0 | ||
Unknown | 7 | ||||
CSF Shunting | |||||
Yes | 53 | 45.8 | 0.074 | 41.1 | 0.055 |
No | 103 | 56.0 | 47.5 | ||
Unknown | 17 | ||||
RTb | |||||
Yes | 139 | 58.4 | <0.001 | 49.3 | <0.001 |
No | 34 | 8.0 | 8.0 | ||
CHTc | |||||
Yes | 98 | 62.1 | <0.001 | 51.2 | 0.001 |
No | 75 | 38.9 | 38.9 | ||
Institution | |||||
A | 153 | 53.3 | 0.184 | 46.9 | 0.238 |
B | 20 | 40.0 | 40.0 |
involving brain stem or IV ventricle floor by the tumor.
indicating postoperative primary radiation therapy.
indicating postoperative primary chemotherapy.
Institution A = Huashan Hospital.
Institution B = Southwest Hospital.