Table 3. Univariate analysis of histological and molecular subgroups for OS and EFS in medulloblastoma patients (n = 173).
Factors | No. of cases | 5-year OS(%) | p-value | 5-year EFS(%) | p-value |
Histological subgroups | |||||
CMB | 119 | 51.7 | 0.187 | 46.7 | 0.643 |
DMB | 45 | 61.0 | 45.7 | ||
AMB | 9 | 18.5 | 18.5 | ||
Molecular subgroups | |||||
SHH | 40 | 50.4 | 0.182 | 40.9 | 0.277 |
WNT | 37 | 69.2 | 59.2 | ||
Non-SHH/WNT | 96 | 45.9 | 41.0 | ||
Molecular subgroupsa | |||||
WNT | 30 | 83.3 | 0.028 | 78.6 | 0.081 |
Other | 118 | 54.9 | 44.6 |
CMB = Classic medulloblastoma, DMB = Desmoplastic/nodular medulloblastoma, AMB = Large-cell/anaplastic medulloblastoma, SHH = SHH pathway medulloblastoma, WNT = WNT pathway medulloblastoma, Non-SHH/WNT = Non-SHH/WNT pathway medulloblastoma.
those patients who did not receive any adjuvant therapies after primary resection were excluded.