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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: J Carcinog Mutagen. 2013 Aug 16;4(3):147. doi: 10.4172/2157-2518.1000147

Table 1.

Consequences of GSK3β inhibition in pancreatic cancer cells.

Inhibitor Cell type Consequences Reference
AR-A014418 Panc-1 Decreased proliferation and tumor growth, gemcitabine sensitization 39
AR-A014418 Panc-1, MiaPaCa-2, BxPC-3 Decreased proliferation, gemcitabine sensitization (in vitro & in vivo), radiosensitization, decreased migration & invasion 36
siGSK3β & AR-A014418 MiaPaCa-2, Panc-1 Decreased NFκB activity, caspase-3 cleavage, decreased proliferation 40
AR-A014418 BxPC-3, Panc-1, HPAC, PK-1, PK-8 Decreased proliferation, no gemcitabine sensitization (except Panc-1) 43
AR-A014418 Panc-1, BxPC-3 Increased TRAIL-induced apoptosis (in vitro & in vivo) 38
AR-A014418, shGSK3β, SB216763 MiaPaCa-2, BxPC-3 Decreased proliferation, increased apoptosis 26
shGSK3β, LiCI BxPC-3 & Panc-1 Resistance to radiation (in vitro & in vivo) 37
siGSK3β Panc-1 Resistance to radiation, increased HGF, c-Met activation [Figure 4]