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. 2014 Jun 16;9(6):e100188. doi: 10.1371/journal.pone.0100188

Figure 8. Effects of chronic treatments with anticonvulsants lamotrigine and topiramate on behavior of Gria1−/− mice.

Figure 8

Cumulative locomotor activities of Gria1−/− and WT mice treated chronically with lamotrigine- or topiramate-supplemented chow for 5-min time intervals (A, C) and for the whole 2-h experiment (B, D). Data are means ± SEM (n = 8–27). In A and C, the earliest significant point from the control activity has been marked by #(p<0.05). Topiramate treatment reduced the time spent in open arms of elevated-plus maze (E; means ± SEM, n = 9–12) and increased immobility time in forced swimming test (F; means ± SEM, n = 11–12) in Gria1−/− mice. **p<0.01, ***p<0.001 for the difference between genotypes after the same treatment; # p<0.05, ### p<0.001 for the difference from the control within the same genotype (two-way ANOVA followed by Bonferroni post-hoc test).