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Functional coupling between CaV channels and secretory vesicles via the CaVβ subunit. (a) RIMs anchor synaptic vesicles next to channels through its interaction with zone-specific proteins (Rab3) and the CaVβ subunit. After depolarization, RIMs regulate the time course of channel inactivation resulting in a sustained Ca2+ influx. This molecular organization favors hormone and neurotransmitter release.
