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. 2014 Apr 10;114(11):6040–6079. doi: 10.1021/cr400341h

Table 3. Neoplastic Changes in rasH2 Mice Implanted with CNT, Carbon Black, Solvent, or N-Methyl-N-nitrosourea (MNU) Solutiona.

    total number
    control carbon black CNT MNU
organ diagnosis 10 10 10 10
skin (back area) papilloma 0 0 0 2
  keratoacanthoma 0 0 0 0
skin (face) papilloma 0 0 0 3
  keratoacanthoma 0 0 0 0
skin (thigh) papilloma 0 0 0 1
  keratoacanthoma 0 0 0 0
spleen inflammatory pseudotumor 0 0 1 0
  hemangioma 0 1 0 0
hematopoietic system malignant lymphoma 0 0 0 2
  epithelial thymoma 0 0 0 0
kidneys hemangioma 0 0 0 0
pancreas hemangioma 0 0 0 0
lungs adenocarcinoma 0 0 0 0
  adenoma 0 1 0 1
  hemangioma 0 0 0 0
forestomach papilloma 0 0 0 10b
  basal cell tumor 0 0 0 0
  squamous cell carcinoma 0 0 0 0
perineal papilloma 0 0 0 5c
a

Adapted with permission from ref (98). Copyright 2012 Nature Publishing Group.

b

Significant differences at p = 0.0000054125 (Fisher’s direct method).

c

Significant differences at p = 0.016254 (Fisher’s direct method).