Table 2.

Risk-allele frequencies, p-values for Hardy–Weinberg equilibrium and associations with breast cancer for each SNP, overall and stratified by age group

SNP	Case		Control		OR	(95% CI)	p
	Freq.	PHWE	Freq.	PHWE
All*
rs2981582 (FGFR2)	0.44	0.6	0.42	0.01	1.09	(0.93–1.28)	0.3
rs3803662 (TOX3)	0.33	0.4	0.27	0.5	1.31	(1.10–1.55)	0.002
rs889312 (MAP3K1)	0.33	0.2	0.30	0.5	1.15	(0.97–1.36)	0.1
rs13387042 (2q35)	0.51	0.2	0.49	0.05	1.09	(0.94–1.27)	0.3
rs13281615 (8q24)	0.45	0.03	0.39	0.9	1.29	(1.10–1.51)	0.002
rs4415084 (FGF10)	0.45	0.9	0.40	0.4	1.24	(1.05–1.46)	0.01
rs3817198 (LSP1)	0.34	0.5	0.32	0.3	1.11	(0.94–1.31)	0.2
Aged 35 to 39 years
rs2981582 (FGFR2)	0.48	0.5	0.41	0.4	1.32	(1.01–1.73)	0.04
rs3803662 (TOX3)	0.35	0.3	0.31	0.7	1.18	(0.90–1.55)	0.2
rs889312 (MAP3K1)	0.32	0.9	0.33	0.2	0.95	(0.72–1.25)	0.7
rs13387042 (2q35)	0.53	0.08	0.43	1.0	1.43	(1.11–1.84)	0.005
rs13281615 (8q24)	0.44	0.05	0.37	0.2	1.32	(1.01–1.72)	0.04
rs4415084 (FGF10)	0.45	0.4	0.41	0.6	1.19	(0.90–1.58)	0.2
rs3817198 (LSP1)	0.35	0.7	0.37	0.3	0.93	(0.72–1.22)	0.6
Aged 40 to 49 years
rs2981582 (FGFR2)	0.43	0.3	0.42	0.2	1.01	(0.77–1.33)	0.9
rs3803662 (TOX3)	0.34	0.4	0.27	0.3	1.40	(1.03–1.90)	0.03
rs889312 (MAP3K1)	0.33	0.2	0.25	0.004	1.43	(1.07–1.92)	0.02
rs13387042 (2q35)	0.52	1.0	0.50	0.02	1.07	(0.82–1.39)	0.6
rs13281615 (8q24)	0.48	0.8	0.40	0.7	1.39	(1.05–1.85)	0.02
rs4415084 (FGF10)	0.46	1.0	0.41	0.2	1.24	(0.93–1.65)	0.2
rs3817198 (LSP1)	0.33	0.5	0.29	1.0	1.21	(0.90–1.62)	0.2
Aged 50 to 59 years
rs2981582 (FGFR2)	0.41	0.8	0.42	0.04	0.93	(0.69–1.26)	0.7
rs3803662 (TOX3)	0.30	0.1	0.23	0.6	1.40	(1.01–1.94)	0.04
rs889312 (MAP3K1)	0.34	0.5	0.31	0.8	1.14	(0.84–1.56)	0.4
rs13387042 (2q35)	0.50	0.5	0.56	0.52	0.79	(0.59–1.05)	0.1
rs13281615 (8q24)	0.44	0.05	0.40	0.5	1.16	(0.87–1.54)	0.3
rs4415084 (FGF10)	0.44	0.7	0.38	0.02	1.28	(0.95–1.72)	0.1
rs3817198 (LSP1)	0.34	0.5	0.29	0.9	1.27	(0.93–1.73)	0.1

^*ORs adjusted for age group

Freq. = frequency of high-risk allele

P_HWE = p-value for Hardy–Weinberg equilibrium