Table 2.

Pharmacokinetic parameters for intravenous, oral, and subcutaneous ondansetron administered to healthy cats

	i.v.			Oral			SQ
Pharmacokinetic parameter	Median	Range	Mean ± SD	Median	Range	Mean ± SD	Median	Range	Mean ± SD
Cmax (ng/mL)	274	228–1310	447 ± 426	92.7	12–143	87 ± 54	87.7	50.9–172	98 ± 48
Tmax *,† (h)	–	–	–	1.0	0.5–1	0.8 ± 0.3	0.4	0.25–0.5	0.4 ± 0.1
Half-life‡,† (h)	1.6	1.4–3.0	1.8 ± 0.6	1.1	0.9–1.6	1.2 ± 0.3	3.1	2.6–3.8	3.2 ± 0.5
AUC∞* (ng/mL·h)	415	433–740	454 ± 154	148	38–252	156 ± 79	312	237–369	311 ± 53
Vz (L)	28.a5	23–70	29.0 ± 15.3	–	–	–	–	–	–
Vz/F (L)*,†	–	–	–	24.7	17.3–84.3	35.7 ± 25.4	102.4	45.2–160.5	99.3 ± 44.9
CL (L/h/kg)	0.9	0.6–1.4	0.9 ± 0.3	–	–	–	–	–	–
CL/F (L/h/kg)	–	–	–	0.9	0.64–2.5	1.2 ± 0.7	0.9	0.5–1.6	1.0 ± 0.4
Bioavailability†	–	–	–	0.36	0.11–0.5	0.32 ± 0.15	0.70	0.41–1.0	0.75 ± 0.28

Parameters that are significantly different (P < 0.05) are denoted with (*i.v. vs. p.o.; ^†p.o. vs. SQ; ^‡i.v. vs. SQ).