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. 2014 May 26;15(1):400. doi: 10.1186/1471-2164-15-400

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© Sharma et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Nucleotide substitution rates in sex-bias genes per tissue. Mean values with 95% confidence intervals for rate of nucleotide substitutions in coding sequences. (A) d _N /d _S ratios; (B) d _N; and (C) d _S. Male-biased (MB: blue), female-biased (FB: pink), and unbiased (UB: yellow) genes for brain, gonad, and tail. Asterisks above the boxplots indicate a significant difference in substitution rate was found between the sex-biased and unbiased genes using Mann–Whitney U test for non-parametric distributions (**** p < 0.0001; *** p < 0.001; ** p <0.01; * p < 0.05).