Table 5.
Brain | Tail | Gonad | |||||||
---|---|---|---|---|---|---|---|---|---|
(N) | dN/dS | p-value | (N) | dN/dS | p-value | (N) | dN/dS | p-value | |
All | |||||||||
Unbiased | 7386 | 0.097 | 5466 | 0.100 | 1667 | 0.099 | |||
Male-biased | 105 | 0.082 | 0.015 | 279 | 0.096 | 0.474 | 1350 | 0.122 | < 0.0001 |
Female-biased | 653 | 0.129 | < 0.0001 | 266 | 0.119 | < 0.0001 | 1984 | 0.112 | < 0.0001 |
Autosomal | |||||||||
Unbiased | 6061 | 0.096 | 4383 | 0.100 | 1328 | 0.097 | |||
Male-biased | 96 | 0.084 | 0.083 | 221 | 0.094 | 0.576 | 1111 | 0.122 | < 0.0001 |
Female-biased | 542 | 0.131 | < 0.0001 | 199 | 0.119 | < 0.0001 | 1561 | 0.111 | < 0.0001 |
Single Tissue | |||||||||
Unbiased | 2018 | 0.094 | 504 | 0.124 | 104 | 0.135 | (< 0.0001) | ||
Male-biased | 74 | 0.077 | 0.061 | 179 | 0.091 | 0.00014 | 1070 | 0.122 | 0.0038 (< 0.0001) |
Female-biased | 310 | 0.130 | < 0.0001 | 98 | 0.122 | 0.337 | 1368 | 0.108 | 0.00014 (< 0.0001) |
Multiple Tissue | |||||||||
Unbiased | 4043 | 0.096 | 3879 | 0.097 | 1224 | 0.094 | |||
Male-biased | 22 | 0.107 | 0.929 | 42 | 0.107 | 0.452 | 41 | 0.105 | 0.336 |
Female-biased | 232 | 0.132 | < 0.0001 | 101 | 0.116 | 0.0017 | 193 | 0.131 | < 0.0001 |
Highly expressed | |||||||||
Unbiased | 2220 | 0.079 | 1103 | 0.090 | 550 | 0.084 | |||
Male-biased | 23 | 0.076 | 0.328 | 50 | 0.102 | 0.120 | 684 | 0.125 | < 0.0001 |
Female-biased | 183 | 0.115 | < 0.0001 | 40 | 0.104 | 0.191 | 499 | 0.112 | < 0.0001 |
We first compare mean dN/dS values for all sex-biased genes (FDR < 0.1 and median fold-change: brain 1.5 fold; tail 1.7 fold; gonad 3.5 fold) to unbiased genes (FDR > 0.1, log2CPM > 2). We then compare sex-biased genes mapped to autosomal linkage groups only. We also compare those expressed only in a single tissue and multiple tissues separately. In the single tissue gonad set we also compared dN/dS to unbiased genes on autosomal linkage groups only (p-values given in brackets). Finally, we compared only highly expressed genes (>32 CPM). For each comparison we give the number of genes (N), the mean dN/dS, and p-value, with p-values less than 0.0001 in bold.