Table 1. Binding Affinities for CSE and Nicotine at nAChRs.
nAChR subtype | Region analyzed | CSE Ki | CSE 95% CI | Nic Ki | Nic 95% CI |
---|---|---|---|---|---|
α4β2 | VPM/VPL thalamus | 10.34 nM | 7.7–13.8 nM | 16.29 nM | 11.2–23.8 nM |
α3β4 | Medial habenula | 1.112 μM | 0.75–1.66 μM | 1.285 μM | 0.85–1.86 μM |
α3β2 | Superior colliculus | 0.0809 μM | 0.024–0.272 μM | 0.172 μM | 0.032–0.921 μM |
α7 | Dentate gyrus | 32.69 μM | 19.6–54.5 μM | 38.05 μM | 21.42–67.62 μM |