Figure 2.

Cocaine increased glutamate release in pDMS but not DLS. (a) Representative raw traces of sEPSCs from saline- and cocaine-treated animals. Mean (+SEM) whole-cell recordings of sEPSC frequency (b) and amplitude (c) in pDMS and DLS from saline- and cocaine-treated rats. In the presence of TTX (1 μM), the cocaine-mediated increase in mean mEPSC frequency persisted in the pDMS (d) whereas its corresponding amplitude remained unchanged (e). No effects of cocaine were seen in the DLS. The numbers of cells recorded are indicated below the corresponding mean for that condition; N=4–8 neurons. *Significant difference, p<0.05.