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. 2014 Mar 26;39(8):1996–2007. doi: 10.1038/npp.2014.49

Figure 7.

Figure 7

EEG bursts induced by a drug interaction between paroxetine (PRX; 15 mg/kg, i.p.) and clorgyline (CLG; 2 mg/kg, s.c.). Triangles (▾) indicate EEG bursts corresponding to head shaking behavior. Data are expressed as mean (±SEM) counts of bursts. (a) Drug-naive rats. Left panel represents raw EEG traces (15 s each) clipped from the time frame of 0–60 min after drug injection, whereas right panel shows numbers of EEG bursts. PRX alone (15 mg/kg; N=7) had no effect on EEG bursts. Challenge injection of CLG+PRX (N=4) caused significant increases in EEG bursts: **P<0.01. (b) Experimental animals were pretreated with daily CLG (2 mg/kg) for 3, 6, or 13 days and were challenged on days 4, 7, or 14 with CLG+PRX with the PRX dose at 15 mg/kg (N=5–7). Control animals were also challenged with CLG+PRX. Although challenge injection of CLG+PRX produced increases in EEG bursts in the control group and CLG pretreatment groups, there was no significant difference among them (P>0.05, n.s.).