Table 1. Experimental Groups, Pretreatment, and Drug Challenge Protocol.
| Naive | Chronic CLG | ||||||
|---|---|---|---|---|---|---|---|
| Pretreatment | No | No | No | SAL 3–13 days | CLG × 3 days | CLG × 6 days | CLG × 13 days |
| Experimental day | Day 4 | Day 7 | Day 14 | ||||
| Challenge with | SAL+veh | SAL+PRX | CLG+PRX | CLG+veh | CLG+PRX | CLG+PRX | CLG+PRX |
Abbreviations: CLG, clorgyline; PRX, paroxetine; SAL, saline; Veh, vehical.
CLG at a dose of 2 mg/kg, s.c.
PRX at 15 mg/kg, i.p.
SAL and veh at 1 ml/kg, s.c.